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Methods Mol Biol. 2012;798:213-29. doi: 10.1007/978-1-61779-343-1_12.

Analysis of skeletal muscle hypertrophy in models of increased loading.

Author information

1
Department of Neurobiology, University of California, Davis, CA, USA. scbodine@ucdavis.edu

Abstract

Skeletal muscle is a highly adaptive tissue that modifies its size in response to a variety of external stimuli. In adult mammals, skeletal muscle hypertrophy occurs primarily as a response to increases in external loading. Here, we describe the methods that should be used for a comprehensive assessment of muscle hypertrophy in animal models. The methods include the measurement of muscle mass, fiber cross-sectional area, contractile function, and protein concentration.

PMID:
22130839
DOI:
10.1007/978-1-61779-343-1_12
[Indexed for MEDLINE]

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