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Chem Soc Rev. 2012 Mar 21;41(6):2256-82. doi: 10.1039/c1cs15166e. Epub 2011 Nov 30.

Gold nanoparticles in biomedical applications: recent advances and perspectives.

Author information

1
Institute of Biochemistry and Physiology of Plants and Microorganisms, RAS, 13 Pr. Entuziastov, Saratov 410049, Russian Federation.

Abstract

Gold nanoparticles (GNPs) with controlled geometrical, optical, and surface chemical properties are the subject of intensive studies and applications in biology and medicine. To date, the ever increasing diversity of published examples has included genomics and biosensorics, immunoassays and clinical chemistry, photothermolysis of cancer cells and tumors, targeted delivery of drugs and antigens, and optical bioimaging of cells and tissues with state-of-the-art nanophotonic detection systems. This critical review is focused on the application of GNP conjugates to biomedical diagnostics and analytics, photothermal and photodynamic therapies, and delivery of target molecules. Distinct from other published reviews, we present a summary of the immunological properties of GNPs. For each of the above topics, the basic principles, recent advances, and current challenges are discussed (508 references).

PMID:
22130549
DOI:
10.1039/c1cs15166e
[Indexed for MEDLINE]

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