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Curr Opin Neurobiol. 2012 Feb;22(1):111-20. doi: 10.1016/j.conb.2011.11.007. Epub 2011 Nov 28.

Optical highlighter molecules in neurobiology.

Author information

1
Department of Neurobiology, Harvard Medical School, Room 336 Warren Alpert Bldg., 220 Longwood Avenue, Boston, MA 02115, United States. srdatta@hms.harvard.edu

Abstract

The development of advanced optical methods has played a key role in propelling progress in neurobiology. Genetically-encoded fluorescent molecules found in nature have enabled labeling of individual neurons to study their physiology and anatomy. Here we discuss the recent use of both native and synthetic optical highlighter proteins to address key problems in neurobiology, including questions relevant to synaptic function, neuroanatomy, and the organization of neural circuits.

PMID:
22129781
PMCID:
PMC3294064
DOI:
10.1016/j.conb.2011.11.007
[Indexed for MEDLINE]
Free PMC Article
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