Format

Send to

Choose Destination
Head Neck. 2012 Jul;34(7):949-52. doi: 10.1002/hed.21828. Epub 2011 Aug 24.

Serum thyrotropin as a risk factor for thyroid malignancy in euthyroid subjects with thyroid micronodule.

Author information

1
Department of Internal Medicine, Dongguk University School of Medicine, Gyeongju, Korea.

Abstract

BACKGROUND:

An elevated thyroid stimulating hormone (TSH) level is a risk factor for differentiated thyroid cancer. The present study investigated whether TSH is a risk factor for thyroid microcarcinoma (TMC) in euthyroid subjects with a micronodule.

METHODS:

In this cross-sectional study, 483 euthyroid subjects (77 males patients, 406 females patients) with a thyroid micronodule were enrolled and underwent ultrasound guided fine-needle aspiration biopsy. Serum TSH level was measured in every subject. The final diagnostic outcome (malignant or benign) was defined in conjunction with cytology and histology.

RESULTS:

Compared with the patients below the population mean, patients above the population mean had a significantly higher malignancy rate (10.8% vs 4.8%, p = .025). Multiple logistic regression analysis revealed TSH as an independent risk factor for malignancy in euthyroid patients with a micronodule (odds ratio, 1.449; 95% confidence interval, 1.033-2.033; p = .031).

CONCLUSIONS:

Measurement of TSH in subjects with a thyroid micronodule is helpful to estimate cancer risk.

PMID:
22127951
DOI:
10.1002/hed.21828
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center