True hypoglycaemia secondary to treatment with granulocyte colony stimulating factor (G-CSF) in a diabetic patient with non-small cell lung cancer

Jermaine I G Coward; Ravindhi Nathavitharana; Sanjay Popat

doi:10.1016/j.lungcan.2011.11.001

True hypoglycaemia secondary to treatment with granulocyte colony stimulating factor (G-CSF) in a diabetic patient with non-small cell lung cancer

Lung Cancer. 2012 Jan;75(1):133-5. doi: 10.1016/j.lungcan.2011.11.001. Epub 2011 Nov 27.

Authors

Jermaine I G Coward¹, Ravindhi Nathavitharana, Sanjay Popat

Affiliation

¹ Royal Marsden NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK. jim.coward@gmail.com

PMID: 22126907
DOI: 10.1016/j.lungcan.2011.11.001

Abstract

We report the case of a 61-year-old man with non-small lung cancer with poorly controlled type 2 diabetes mellitus who developed clinically significant hypoglycaemia secondary to a first exposure to granulocyte colony stimulating factor (G-CSF) injections. Whilst artefactual hypoglycaemia during treatment with G-CSF is well recognised, to our knowledge, this is the first report revealing that it can provoke true hypoglycaemia in the absence of leucocytosis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Non-Small-Cell Lung / blood
Carcinoma, Non-Small-Cell Lung / drug therapy*
Diabetes Mellitus, Type 2 / blood*
Granulocyte Colony-Stimulating Factor / adverse effects*
Granulocyte Colony-Stimulating Factor / therapeutic use*
Humans
Hypoglycemia / chemically induced*
Leukocytosis / chemically induced
Lung Neoplasms / blood
Lung Neoplasms / drug therapy*
Male
Middle Aged

Substances

Granulocyte Colony-Stimulating Factor