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J Neuroimmunol. 2012 Jan 18;242(1-2):33-8. doi: 10.1016/j.jneuroim.2011.10.013. Epub 2011 Nov 29.

Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels.

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Osher Center for Integrative Medicine, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.


Activation of glia cells resulting in intrathecal elevation of cytokines and chemokines has been hypothesized in chronic pain syndromes such as fibromyalgia. To our knowledge, this is the first study assessing intrathecal concentrations of pro-inflammatory substances in fibromyalgia. We report elevated cerebrospinal fluid and serum concentrations of interleukin-8, but not interleukin-1beta, in FM patients. This profile is in accordance with FM symptoms being mediated by sympathetic activity rather than dependent on prostaglandin associated mechanisms and supports the hypothesis of glia cell activation in response to pain mechanisms.

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