Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

Peng-Yu Yang; Min Wang; Cynthia Y He; Shao Q Yao

doi:10.1039/c1cc16178d

Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei

Chem Commun (Camb). 2012 Jan 21;48(6):835-7. doi: 10.1039/c1cc16178d. Epub 2011 Nov 28.

Authors

Peng-Yu Yang¹, Min Wang, Cynthia Y He, Shao Q Yao

Affiliation

¹ Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.

PMID: 22124229
DOI: 10.1039/c1cc16178d

Abstract

We report herein the design, synthesis and application of K11777-derived activity-based probes (ABPs) allowing in situ profiling and identification of potential cellular targets of K11777 in Trypanosoma brucei.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antiparasitic Agents / pharmacology*
Cysteine Proteinase Inhibitors / pharmacology*
Dipeptides / pharmacology*
Gene Expression Profiling
Phenylalanine / analogs & derivatives
Piperazines
Proteomics
Protozoan Proteins / metabolism*
Tosyl Compounds
Trypanosoma brucei brucei / drug effects*
Trypanosoma brucei brucei / metabolism
Vinyl Compounds / pharmacology*

Substances

Antiparasitic Agents
Cysteine Proteinase Inhibitors
Dipeptides
Piperazines
Protozoan Proteins
Tosyl Compounds
Vinyl Compounds
N-pip-phenylalanine-homophenylalanine-vinyl sulfone phenyl
Phenylalanine