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Cold Spring Harb Symp Quant Biol. 2011;76:113-20. doi: 10.1101/sqb.2011.76.010660. Epub 2011 Nov 28.

The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status.

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Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.


A Caenorhabditis elegans insulin-like signaling pathway regulates development, metabolism, and longevity. We detected abundant DAF-2 insulin-like receptor protein mainly in the nervous system, consistent with the assignment of DAF-2 pathway regulation of longevity to the nervous system. DAF-2 abundance in the nervous system is dependent on food intake, showing environmental modulation of pathway signaling. DAF-2 abundance is not dependent on downstream PI-3 kinase to DAF-16 transcription factor signaling. The modulation of DAF-2 protein level by nutritional status may constitute an important component in the irreversible commitment to dauer arrest.

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