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Microbes Infect. 2012 Mar;14(3):217-27. doi: 10.1016/j.micinf.2011.11.001. Epub 2011 Nov 15.

A battle for iron: host sequestration and Staphylococcus aureus acquisition.

Author information

1
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Ave., South, A5102 MCN, Nashville, TN 37232-2363, USA.

Abstract

The use of iron as an enzymatic cofactor is pervasive in biological systems. Consequently most living organisms, including pathogenic bacteria, require iron to survive and replicate. To combat infection vertebrates have evolved sophisticated iron sequestration systems against which, pathogenic bacteria have concomitantly evolved equally elaborate iron acquisition mechanisms.

PMID:
22123296
PMCID:
PMC3785375
DOI:
10.1016/j.micinf.2011.11.001
[Indexed for MEDLINE]
Free PMC Article

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