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Nat Genet. 2011 Nov 27;44(1):58-61. doi: 10.1038/ng.993.

Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk.

Author information

1
Molecular and Population Genetics, Division of Genetics and Epidemiology, Institute of Cancer Research, Surrey, UK.
2
Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research, Surrey, UK.
3
Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
4
German Cancer Research Center, Heidelberg, Germany.
5
University of Leeds, Leeds, UK.
6
Cytogenetics Group, Wessex Regional Cytogenetic Laboratory, Salisbury, UK.
7
Royal Victoria Infirmary, Newcastle-on-Tyne, UK.
8
Institute of Human Genetics, University of Heidelberg, Germany.
9
Institute of Human Genetics, University of Bonn, Germany.
10
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
11
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Germany.
12
Molecular and Population Genetics, Wellcome Trust Centre for Human Genetics, Oxford, OX3 7BN, UK.
13
National Centre of Tumour Diseases, Heidelberg, Germany.
14
Center for Primary Health Care Research, Lund University, Malmo, Sweden.
#
Contributed equally

Abstract

To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 × 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 × 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 × 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

PMID:
22120009
PMCID:
PMC5108406
DOI:
10.1038/ng.993
[Indexed for MEDLINE]
Free PMC Article

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