Abstract
The ethylacetate and n-butanol fractions of ethanolic extract of Platanus orientalis leaves led to the isolation of new acylated flavonol glycoside as 3',5,7-trihydroxy-4'-methoxyflavonol 3-[O-2-O-(2,4-Dihydroxy)-E-cinnamoyl-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl (1→2)]-β-D-glucopyranoside, along with seven known compounds. All the compounds were characterized by NMR including 2D NMR techniques. The isolates were evaluated for NF-κB, nitric oxide (NO), aromatase and QR2 chemoprevention activities and some of them appeared to be modestly active.
Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved.
MeSH terms
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Acylation
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Aromatase / metabolism
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Cell Line
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Chemoprevention
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Female
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Flavonols / chemistry
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Flavonols / isolation & purification
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Flavonols / pharmacology*
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Humans
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Magnetic Resonance Spectroscopy
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Magnoliopsida / chemistry*
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Molecular Structure
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NF-kappa B / metabolism
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Nitric Oxide / metabolism
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry
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Quinone Reductases / antagonists & inhibitors
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Quinone Reductases / metabolism
Substances
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Flavonols
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Glycosides
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NF-kappa B
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Plant Extracts
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Nitric Oxide
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Aromatase
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NRH - quinone oxidoreductase2
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Quinone Reductases