Acylated flavonol glycoside from Platanus orientalis

Fitoterapia. 2012 Mar;83(2):281-5. doi: 10.1016/j.fitote.2011.11.004. Epub 2011 Nov 9.

Abstract

The ethylacetate and n-butanol fractions of ethanolic extract of Platanus orientalis leaves led to the isolation of new acylated flavonol glycoside as 3',5,7-trihydroxy-4'-methoxyflavonol 3-[O-2-O-(2,4-Dihydroxy)-E-cinnamoyl-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranosyl (1→2)]-β-D-glucopyranoside, along with seven known compounds. All the compounds were characterized by NMR including 2D NMR techniques. The isolates were evaluated for NF-κB, nitric oxide (NO), aromatase and QR2 chemoprevention activities and some of them appeared to be modestly active.

MeSH terms

  • Acylation
  • Aromatase / metabolism
  • Cell Line
  • Chemoprevention
  • Female
  • Flavonols / chemistry
  • Flavonols / isolation & purification
  • Flavonols / pharmacology*
  • Glycosides / chemistry
  • Glycosides / isolation & purification
  • Glycosides / pharmacology*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Magnoliopsida / chemistry*
  • Molecular Structure
  • NF-kappa B / metabolism
  • Nitric Oxide / metabolism
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry
  • Quinone Reductases / antagonists & inhibitors
  • Quinone Reductases / metabolism

Substances

  • Flavonols
  • Glycosides
  • NF-kappa B
  • Plant Extracts
  • Nitric Oxide
  • Aromatase
  • NRH - quinone oxidoreductase2
  • Quinone Reductases