Send to

Choose Destination
Bioresour Technol. 2012 Jan;104:537-46. doi: 10.1016/j.biortech.2011.10.029. Epub 2011 Nov 4.

Optimization of microalgal productivity using an adaptive, non-linear model based strategy.

Author information

Chemical and Materials Engineering Department, University of Alberta, Edmonton, Canada T6G 2V4.


The optimization of biomass and oil productivities in heterotrophic cultures of Auxenochlorella protothecoides was achieved using a non-linear model-based approach. A 10-fold increase in the average biomass productivity, and a 16-fold increase in the maximum productivity, was observed with respect to batch cultures as a result of the proposed optimization strategy. Final cell density in the optimized culture was 144 g/L (dry weight), with 49.4%w/w oil content. Maximum lipid productivity was 20.16 g/L d, achieved during the exponential growth phase at an average cell density of 86 g/L. Lipid productivity in the optimized microalgal culture was higher than previously reported values for other oleaginous microorganisms. Oil composition analysis showed that the oil has a high quality as biodiesel precursor. The higher productivity and excellent lipid profile of the optimized microalgal culture make A. protothecoides an exceptional source for biodiesel production and a potential source of single cell oil for other applications.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center