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Curr Opin Neurobiol. 2012 Feb;22(1):79-85. doi: 10.1016/j.conb.2011.11.002. Epub 2011 Nov 24.

Genetics in non-genetic model systems.

Author information

1
Department of Neurobiology, University of Massachusetts Medical School, Worcester, 364 Plantation Street, MA 01655, USA. Carlos.Lois@umassmed.edu

Abstract

The past few decades have seen the field of genetic engineering evolve at a rapid pace, with neuroscientists now equipped with a wide range of tools for the manipulation of an animal's genome in order to study brain function. However, the number of species to which these technologies have been applied, namely the fruit fly, C. elegans, zebrafish and mouse, remains relatively few. This review will discuss the variety of approaches to genetic modification that have been developed in such traditional 'genetic systems', and highlight the progress that has been made to translate these technologies to alternative species such as rats, monkeys and birds, where certain neurobiological questions may be better studied.

PMID:
22119141
PMCID:
PMC3320209
DOI:
10.1016/j.conb.2011.11.002
[Indexed for MEDLINE]
Free PMC Article

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