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Curr Opin Immunol. 2011 Dec;23(6):721-31. doi: 10.1016/j.coi.2011.10.007. Epub 2011 Nov 24.

B cells and autoimmunity.

Author information

1
Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States. pillai@helix.mgh.harvard.edu

Abstract

There is a growing appreciation for the role for B cells in autoimmune disorders in which inflammation is driven by T cells, in addition to the well-established role for B cells in autoimmune disorders characterized by pathogenic auto-antibodies. Current information on tolerance checkpoints in B cells, B cell depletion, BAFF blockade, regulatory B cells and clonal ignorance mediated by the SIAE/Siglec pathway will be reviewed.

PMID:
22119110
PMCID:
PMC3268048
DOI:
10.1016/j.coi.2011.10.007
[Indexed for MEDLINE]
Free PMC Article

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