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Trends Genet. 2012 Feb;28(2):62-9. doi: 10.1016/j.tig.2011.10.006. Epub 2011 Nov 24.

A better prognosis for genetic association studies in mice.

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1
Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

Although inbred mouse strains have been the premier model organism used in biomedical research, multiple studies and analyses have indicated that genome-wide association studies (GWAS) cannot be productively performed using inbred mouse strains. However, there is one type of GWAS in mice that has successfully identified the genetic basis for many biomedical traits of interest: haplotype-based computational genetic mapping (HBCGM). Here, we describe how the methodological basis for a HBCGM study significantly differs from that of a conventional murine GWAS, and how an integrative analysis of its output within the context of other 'omic' information can enable genetic discovery. Consideration of these factors will substantially improve the prognosis for the utility of murine genetic association studies for biomedical discovery.

PMID:
22118772
PMCID:
PMC3268904
DOI:
10.1016/j.tig.2011.10.006
[Indexed for MEDLINE]
Free PMC Article
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