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Cell. 2011 Nov 23;147(5):983-91. doi: 10.1016/j.cell.2011.11.004.

Intravital imaging.

Author information

1
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. mpittet@mgh.harvard.edu

Abstract

Until recently, the idea of observing life deep within the tissues of a living mouse, at a resolution sufficient to pick out cellular behaviors and molecular signals underlying them, remained a much-coveted dream. Now, a new era of intravital fluorescence microscopy has dawned. In this Primer, we review the technologies that made this revolution possible and demonstrate how intravital imaging is beginning to provide quantitative and dynamic insights into cell biology, immunology, tumor biology, and neurobiology.

PMID:
22118457
PMCID:
PMC3824153
DOI:
10.1016/j.cell.2011.11.004
[Indexed for MEDLINE]
Free PMC Article

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