Abstract
This article provides a brief review of the acute pain mechanism as it relates to the effects of a surgical insult. A brief understanding of the physiologic modulation of acute pain establishes a rational framework for the concept of preemptive and postoperative analgesia. A brief review of commonly used analgesic agents is presented. Research in pain management and new drug development is ongoing as new concepts in neurophysiology and pharmacology are being elucidated.
Copyright © 2012 Elsevier Inc. All rights reserved.
MeSH terms
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Acute Pain / physiopathology
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Acute Pain / therapy*
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Cyclooxygenase 2 Inhibitors / therapeutic use
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Excitatory Amino Acids / physiology
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Humans
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Narcotics / therapeutic use
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Neuropeptides / physiology
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Nociceptive Pain / physiopathology
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Nociceptors / physiology
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Oral Surgical Procedures* / adverse effects
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Pain, Postoperative / physiopathology
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Pain, Postoperative / prevention & control
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Pain, Postoperative / therapy*
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Synaptic Transmission / physiology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Cyclooxygenase 2 Inhibitors
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Excitatory Amino Acids
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Narcotics
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Neuropeptides