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Surv Ophthalmol. 2011 Nov-Dec;56(6):511-21. doi: 10.1016/j.survophthal.2011.05.001.

Emerging treatments for choroidal metastases.

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1
Wilmer Eye Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Abstract

It has been over a century since Perls described the first case of choroidal metastasis. For the next six decades only 230 cases were described in the literature. Today, however, ocular metastasis is recognized as the most common intraocular malignancy. Thanks to recent advances in treatment options for metastatic disease, patients are living longer, and choroidal metastases will become an increasingly important issue for oncologists and ophthalmologists alike. We summarize the current knowledge of choroidal metastases and examine their emerging systemic and local therapies. Targeted therapies for metastatic lung, breast, and colon cancer--the most common causes of choroidal metastases--are reviewed in detail with the goal of identifying the most effective treatment strategies.

PMID:
22117885
PMCID:
PMC4732700
DOI:
10.1016/j.survophthal.2011.05.001
[Indexed for MEDLINE]
Free PMC Article
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