Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Immunol. 2011 Nov 25;11(12):852-63. doi: 10.1038/nri3108.

The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses.

Author information

1
MRC Centre for Immune Regulation, University of Birmingham Medical School, Birmingham, UK. L.S.Walker@bham.ac.uk

Abstract

The T cell protein cytotoxic T lymphocyte antigen 4 (CTLA4) was identified as a crucial negative regulator of the immune system over 15 years ago, but its mechanisms of action are still under debate. It has long been suggested that CTLA4 transmits an inhibitory signal to the cells that express it. However, not all the available data fit with a cell-intrinsic function for CTLA4, and other studies have suggested that CTLA4 functions in a T cell-extrinsic manner. Here, we discuss the data for and against the T cell-intrinsic and -extrinsic functions of CTLA4.

PMID:
22116087
DOI:
10.1038/nri3108
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center