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Vaccine. 2012 Apr 19;30(19):2921-7. doi: 10.1016/j.vaccine.2011.11.006. Epub 2011 Nov 21.

Is there a future for a Staphylococcus aureus vaccine?

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University of Wisconsin, Medical Microbiology/Immunology, 835 Asa Gray, Ann Arbor, MI 48105, United States.


Multiple attempts to develop a vaccine to prevent Staphylococcus aureus infections have failed. To date, all have been based upon the development of opsonic antibodies. New information suggests that cell mediated immunity may be critical for protection against S. aureus infections. The arm of the immune system that provides the protection contains the Th17/IL-17 axis. Th17 cells release IL-17, which are important for mobilization and activation of neutrophils. Naturally, antibodies aid the neutrophils in the uptake and killing of staphylococci, but immune globulin does not seem to be sufficient to afford protection. New approaches that focus on Th17/IL-17 may allow for the development of a successful S. aureus vaccine.

[Indexed for MEDLINE]

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