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J Clin Psychiatry. 1990 Sep;51 Suppl:18-22.

Increased deep sleep after trazodone use: a double-blind placebo-controlled study in healthy young adults.

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Sleep Disorders Center, Sentara Norfolk General Hospital, VA 23507.


The effects of trazodone on sleep were compared with those of placebo and the sedating tricyclic antidepressant trimipramine in a double-blind crossover study in six healthy young men. Only trazodone significantly increased deep sleep without otherwise altering the normal architecture of sleep. The alpha-adrenergic receptor-blocking property of trazodone and a relative lack of noradrenergic reuptake blocking and the lack of anticholinergic effects are hypothesized to be responsible for the effects on sleep.

[Indexed for MEDLINE]

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