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Bioorg Med Chem Lett. 2012 Jan 1;22(1):380-6. doi: 10.1016/j.bmcl.2011.10.116. Epub 2011 Nov 6.

3-mercapto-1,2,4-triazoles and N-acylated thiosemicarbazides as metallo-β-lactamase inhibitors.

Author information

1
The University of Queensland, School of Chemistry and Molecular Biosciences, Brisbane, Qld 4072, Australia.

Abstract

The production of β-lactamases is an effective strategy by which pathogenic bacteria can develop resistance against β-lactam antibiotics. While inhibitors of serine-β-lactamases are widely used in combination therapy with β-lactam antibiotics, there are no clinically available inhibitors of metallo-β-lactamases (MBLs), and so there is a need for the development of such inhibitors. This work describes the optimisation of a lead inhibitor previously identified by fragment screening of a compound library. We also report that thiosemicarbazide intermediates in the syntheses of these compounds are also moderately potent inhibitors of the IMP-1 MBL from Pseudomonas aeruginosa. The interactions of these inhibitors with the active site of IMP-1 were examined using in silico methods.

PMID:
22115595
DOI:
10.1016/j.bmcl.2011.10.116
[Indexed for MEDLINE]

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