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Int J Antimicrob Agents. 2012 Feb;39(2):168-72. doi: 10.1016/j.ijantimicag.2011.10.005. Epub 2011 Nov 23.

Rapid emergence and spread of OXA-48-producing carbapenem-resistant Enterobacteriaceae isolates in Belgian hospitals.

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National Reference Laboratory for Antibiotic Resistance Monitoring in Gram-negative Bacteria, CHU Mont-Godinne, Université Catholique de Louvain, 1 avenue Dr Gaston Thérasse, B-5530 Yvoir, Belgium.


During a polymerase chain reaction (PCR)-based surveillance study of β-lactam resistance, 19 OXA-48-positive enterobacterial isolates were detected at nine Belgian hospitals from January 2010 to April 2011. Most cases were presumed to have been locally acquired and were detected in patients who had not travelled abroad. Clonally related outbreaks occurred in two different cities. The majority of isolates co-produced several β-lactamases as well as non-β-lactam resistance genes. This report highlights the rapid emergence and spread of OXA-48-producing Enterobacteriaceae in Belgium.

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