Format

Send to

Choose Destination
See comment in PubMed Commons below
J Crohns Colitis. 2011 Dec;5(6):592-7. doi: 10.1016/j.crohns.2011.06.002. Epub 2011 Jun 30.

Prediction of disease complication occurrence in Crohn's disease using phenotype and genotype parameters at diagnosis.

Author information

1
Gastroenterology Department, Rambam Health Center, Haifa, Israel. y_mazor@rambam.health.gov.il, yoavmazor@gmail.com

Abstract

BACKGROUND AND AIMS:

Complications associated with Crohn's disease (CD) are common and influence treatment decisions and outcomes. Appropriate early treatment may offer a therapeutic advantage to patients. The aim of our study was to indentify predictive factors for occurrence of complications at the time of CD diagnosis.

METHODS:

The study population consisted of 269 CD patients treated during a ten year period. Risk factors compared between complicated and non-complicated disease included phenotypical characteristics, disease classification and the presence of NOD2/CARD15 mutations and single nucleotide polymorphisms in selected autophagy and phagosome genes.

RESULTS:

Complete data was obtained for 146 patients with an average follow up of 12years. Sixty five patients (44%) developed a complication during follow up. The only independent risk factors associated with developing a complication were smoking and male gender. There was no association between developing complications and the presence of selected SNPs (P=0.07 for Tyrosine residue on both alleles in NCF4 SNP rs4821544 and P=0.06 for a Guanine residue on both alleles in ATG16L SNP rs2241880). Multivariate analysis using a backwards logistic regression model left only male gender as an independent statistically significant association with complicated disease (OR 2.6017, 95% CI: 1.17 to 5.75). The median time to developing a complication was 4years, and the most common complication was the need for surgical intervention (54%).

CONCLUSIONS:

In the present study, a risk factor for developing CD complication was male gender. Further studies are warranted to assess additional risk factors and how such findings should affect therapy.

PMID:
22115380
DOI:
10.1016/j.crohns.2011.06.002
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center