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Int J Alzheimers Dis. 2011;2011:572495. doi: 10.4061/2011/572495. Epub 2011 Oct 23.

Potential peripheral biomarkers for the diagnosis of Alzheimer's disease.

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Banner Sun Health Research Institute, Sun City, AZ 85351, USA.


Advances in the discovery of a peripheral biomarker for the diagnosis of Alzheimer's would provide a way to better detect the onset of this debilitating disease in a manner that is both noninvasive and universally available. This paper examines the current approaches that are being used to discover potential biomarker candidates available in the periphery. The search for a peripheral biomarker that could be utilized diagnostically has resulted in an extensive amount of studies that employ several biological approaches, including the assessment of tissues, genomics, proteomics, epigenetics, and metabolomics. Although a definitive biomarker has yet to be confirmed, advances in the understanding of the mechanisms of the disease and major susceptibility factors have been uncovered and reveal promising possibilities for the future discovery of a useful biomarker.

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