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J Cyst Fibros. 2012 Mar;11(2):131-6. doi: 10.1016/j.jcf.2011.10.005. Epub 2011 Nov 22.

Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation.

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1
Division of Pulmonary Medicine, University Hospital, 8091 Zurich, Switzerland.

Abstract

BACKGROUND:

Diabetes mellitus (DM) is common in CF and associated with more severe disease. It is unclear whether DM influences outcome of lung transplantation (LTx).

METHODS:

One hundred twenty-three CF patients evaluated for LTx at our centre were included. Survival was calculated.

RESULTS:

Patients with and without DM did not differ with regard to gender, age, FEV(1) and BMI prior to LTx. Eighty patients (65%) had a diagnosis of DM before and 13 (11%) only after LTx. Recipients with DM had a significantly higher 1- and 5-year survival (89% and 71%) than those without (71% and 51%). In the multivariate Cox-regression analysis, DM had no impact on LTx-survival.

CONCLUSIONS:

One- and five-year survival rates after LTx tend to be better in CF recipients with DM compared to those without DM. No impact of DM on the development of BOS was found.

PMID:
22112935
DOI:
10.1016/j.jcf.2011.10.005
[Indexed for MEDLINE]
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