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Dermatoendocrinol. 2011 Jul;3(3):205-10. doi: 10.4161/derm.3.3.16519. Epub 2011 Jul 1.

Vitamin D receptor (VDR) polymorphisms and skin cancer: A systematic review.

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  • 1Department of Dermatology; The Saarland University Hospital; Homburg, Germany.

Abstract

Skin cancer is the most common cancer in humans. There are several types of skin cancer that include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). The associations of vDr polymorphisms with skin cancer risk are not well characterized so far. Only a few epidemiologic studies have directly addressed the relationship between VDR polymorphisms and the incidence and prognosis of MM. To make the most of the available information on VDR polymorphisms and skin cancer (MM, BCC and SCC), we undertook a systematic review of published studies. In conclusion, data summarized in this review support the concept that the vitamin D endocrine system (VDES) is of importance for pathogenesis and progression of MM and other types of skin cancer.

KEYWORDS:

VDR; basal cell carcinoma; melanoma; polymorphism; skin cancer; squamous cell carcinoma; vitamin D

PMID:
22110781
PMCID:
PMC3219172
DOI:
10.4161/derm.3.3.16519
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