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Clin Dev Immunol. 2012;2012:156867. doi: 10.1155/2012/156867. Epub 2011 Nov 2.

The development of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO genotypes.

Author information

1
Department of Laboratory Medicine, University Hospital of North Norway, 9038 Tromsø, Norway. therese.ahlen@unn.no

Abstract

BACKGROUND:

Maternal alloantibodies against HPA-1a can cross placenta, opsonize foetal platelets, and induce neonatal alloimmune thrombocytopenia (NAIT). In a study of 100, 448 pregnant women in Norway during 1995-2004, 10.6% of HPA-1a negative women had detectable anti-HPA-1a antibodies.

DESIGN AND METHODS:

A possible correlation between the maternal ABO blood group phenotype, or underlying genotype, and severe thrombocytopenia in the newborn was investigated.

RESULTS:

We observed that immunized women with blood group O had a lower risk of having a child with severe NAIT than women with group A; 20% with blood group O gave birth to children with severe NAIT, compared to 47% among the blood group A mothers (relative risk 0.43; 95% CI 0.25-0.75).

CONCLUSION:

The risk of severe neonatal alloimmune thrombocytopenia due to anti-HPA-1a antibodies is correlated to maternal ABO types, and this study indicates that the observation is due to genetic properties on the maternal side.

PMID:
22110529
PMCID:
PMC3216343
DOI:
10.1155/2012/156867
[Indexed for MEDLINE]
Free PMC Article
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