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Case Rep Med. 2011;2011:730250. doi: 10.1155/2011/730250. Epub 2011 Oct 26.

Is Ceftriaxone-Induced Biliary Pseudolithiasis Influenced by UDP-Glucuronosyltransferase 1A1 Gene Polymorphisms?

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1
Third Department of Pediatrics, "Attikon" General University Hospital, 1 Rimini Street, Haidari, 124 62 Athens, Greece.

Abstract

Ceftriaxone (cfx), a third-generation cephalosporin antibiotic, leads to transient cholelithiasis in some children, also known as pseudolithiasis. However, the underlying pathogenetic mechanism of this adverse effect has not yet been elucidated. We describe 3 children with ceftriaxone-induced pseudolithiasis, who were also carriers of the A(TA)(7)TAA polymorphism of the UGT1A1 gene, implying that a cause and effect relation may exist.

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