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Int J Biol Sci. 2011;7(9):1239-56. Epub 2011 Oct 25.

Macrophage migration inhibitory factor (MIF): a key player in protozoan infections.

Author information

1
Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México-UNAM, 54090 Tlalnepantla, Estado de México, México.

Abstract

Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine produced by the pituitary gland and multiple cell types, including macrophages (Mø), dendritic cells (DC) and T-cells. Upon releases MIF modulates the expression of several inflammatory molecules, such as TNF-α, nitric oxide and cyclooxygenase 2 (COX-2). These important MIF characteristics have prompted investigators to study its role in parasite infections. Several reports have demonstrated that MIF plays either a protective or deleterious role in the immune response to different pathogens. Here, we review the role of MIF in the host defense response to some important protozoan infections.

KEYWORDS:

Control of parasite infections; Inflammatory response; Macrophage migration inhibitory factor; Protozoan infections; innate immune response.

PMID:
22110378
PMCID:
PMC3221362
DOI:
10.7150/ijbs.7.1239
[Indexed for MEDLINE]
Free PMC Article

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