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Nat Chem. 2011 Oct 23;3(12):963-8. doi: 10.1038/nchem.1177.

Stability of quantum dots in live cells.

Author information

1
Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, Massachusetts 01003, USA.

Abstract

Quantum dots are highly fluorescent and photostable, making them excellent tools for imaging. When using these quantum dots in cells and animals, however, intracellular biothiols (such as glutathione and cysteine) can degrade the quantum dot monolayer, compromising function. Here, we describe a label-free method to quantify the intracellular stability of monolayers on quantum dot surfaces that couples laser desorption/ionization mass spectrometry with inductively coupled plasma mass spectrometry. Using this new approach we have demonstrated that quantum dot monolayer stability is correlated with both quantum dot particle size and monolayer structure, with appropriate choice of both particle size and ligand structure required for intracellular stability.

Comment in

  • Nanomedicine (Lond). 2012 Apr;7(4):473-4.
PMID:
22109277
PMCID:
PMC3228364
DOI:
10.1038/nchem.1177
[Indexed for MEDLINE]
Free PMC Article

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