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Opt Express. 2011 Nov 7;19(23):22929-35. doi: 10.1364/OE.19.022929.

On-chip modulation of evanescent illumination and live-cell imaging with polymer waveguides.

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  • 1Department of Physics, Science Institute, University of Iceland, Dunhagi 3,IS-107 Reykjavik, Iceland.

Abstract

Imaging of live cells was carried out using evanescent-wave excitation on a polymer waveguide chip. Integrated waveguide-based interferometric light modulators were fabricated in order to demonstrate on-chip control of excitation light, e.g., for time-lapse fluorescence microscopy. When combined with a sensitive high-resolution imaging system, the integrated waveguide-excitation platform provides an ideal method of near-surface studies of live cells, where photobleaching and/or phototoxicity effects are of critical concern.

PMID:
22109170
[PubMed - indexed for MEDLINE]
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