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Pediatr Blood Cancer. 2012 Apr;58(4):633-5. doi: 10.1002/pbc.23371. Epub 2011 Nov 21.

Myelosuppression and infectious complications in children with Down syndrome and acute lymphoblastic leukemia.

Author information

1
Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA. krrabin@txch.org

Abstract

Children with Down syndrome (DS) bear an increased risk of acute lymphoblastic leukemia (ALL) and treatment complications. We compared blood counts and toxicities in 22 DS and 44 non-DS ALL patients. Patients with DS had deeper, longer neutrophil and monocyte count nadirs; more toxicities (HR 2.0, P = 0.0005); longer hospitalizations (HR 1.4, P < 0.0001); and more frequent microbiologically documented infections (HR 5.7, P = 0.0019), mucositis (HR 29.0, P = 0.0006), and cellulitis (HR 3.0, P = 0.033). Severe neutropenia, monocytopenia, and increased cellulitis in DS-ALL suggest the importance of skin hygiene, vigilance and aggressive treatment of cutaneous infections.

PMID:
22106003
PMCID:
PMC3279631
DOI:
10.1002/pbc.23371
[Indexed for MEDLINE]
Free PMC Article

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