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J Surg Oncol. 2012 Sep 1;106(3):260-6. doi: 10.1002/jso.22153. Epub 2011 Nov 21.

Clinical significance of microRNA-155 expression in human breast cancer.

Author information

1
Department of General Surgery, The First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, China.

Abstract

BACKGROUND:

The aim of this study is to investigate clinical significance of miR-155 expression in breast cancer.

METHODS:

TaqMan real-time RT-PCR was performed to detect miR-155 expression in breast cancer tissues. The correlation of miR-155 expression with clinicopathological factors and prognosis of breast cancer patients was analyzed. Then, the prognostic value of miR-155 expression was analyzed by univariate and multivariate analyses. Moreover, the effect of miR-155 expression on phenotypes of breast cancer cell was determined by antisense technology.

RESULTS:

The relative expression of miR-155 was significantly higher in breast cancer tissues than in corresponding nontumor tissues. High miR-155 expression was correlated with higher tumor grade, advanced tumor stage and lymph node metastasis (P = 0.012, 0.001, and 0.003, respectively). Kaplan-Meier survival analysis indicated that the disease-free and overall survival rates of high miR-155 group were significantly lower than those of low miR-155 group (P = 0.038 and 0.029, respectively). Multivariate analysis showed that high miR-155 expression was a poor prognostic factor (P = 0.009). Furthermore, antisense targeting miR-155 could inhibit growth, induce cell arrest in G(0) /G(1) phase, enhance apoptosis, and increase radiosensitivity in breast cancer cells.

CONCLUSIONS:

MiR-155 expression might be an independent prognostic factor and a therapeutic target for human breast cancer.

PMID:
22105810
DOI:
10.1002/jso.22153
[Indexed for MEDLINE]

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