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Cerebrovasc Dis. 2011;32(6):528-34. doi: 10.1159/000331466. Epub 2011 Nov 18.

Cerebral microbleeds: histopathological correlation of neuroimaging.

Author information

1
Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, B.C., Canada. ashkan.sho@gmail.com

Abstract

BACKGROUND:

In recent years, there has been a growing interest in cerebral microbleeds (CMBs) and their role in cerebrovascular disease. A few studies have investigated the histopathological correlation between CMBs and neuroimaging findings. We conducted a systematic review in an attempt to characterize the pathological and radiological correlation.

METHODS:

A systematic literature search was conducted for studies in which CMBs were characterized histopathologically and correlated with MRI findings.

RESULTS:

Five studies met the inclusion criteria, with a total of 18 patients. Hemosiderin deposition was reported in 42 CMBs (49%), while 16 CMBs (19%) were described as old hematomas which stained for iron, 13 (15%) had no associated specific pathology, 11 (13%) contained intact erythrocytes, 1 (1%) was due to vascular pseudocalcification, 1 (1%) was a microaneurysm and 1 (1%) was a distended dissected vessel. Lipofibrohyalinosis was the most prominent associated vascular finding. Amyloid angiopathy was present primarily in patients with dementia.

CONCLUSIONS:

Although histopathological associations have been observed using MRI in patients with CMBs, the findings have yet to be validated and further research is warranted.

PMID:
22104448
DOI:
10.1159/000331466
[Indexed for MEDLINE]
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