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Epilepsy Res. 2012 Jul;100(3):218-23. doi: 10.1016/j.eplepsyres.2011.09.027. Epub 2011 Nov 21.

Cerebral ketone metabolism during development and injury.

Author information

1
Department of Neurosurgery, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7039, USA. mprins@mednet.ucla.edu

Abstract

Cerebral metabolism of ketones is a normal part of the process of brain development. While the mature brain relies on glucose as a primary fuel source, metabolism of ketone bodies remains an alternative energy source under conditions of starvation. The neuroprotective properties of brain ketone metabolism make this alternative substrate a viable therapeutic option for various pathologies. Since the ability to revert to utilizing ketones as an alternative substrate is greatest in the younger post-weaned brain, this particular therapeutic approach remains an untapped resource particularly for pediatric pathological conditions.

PMID:
22104087
PMCID:
PMC3306503
DOI:
10.1016/j.eplepsyres.2011.09.027
[Indexed for MEDLINE]
Free PMC Article

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