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J Dermatolog Treat. 2013 Aug;24(4):275-7. doi: 10.3109/09546634.2011.641937. Epub 2011 Dec 27.

Topical dose justification: benzoyl peroxide concentrations.

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1
University of California Medical School, San Francisco, CA 94143, USA. a.brand@live.at

Abstract

BACKGROUND:

Benzoyl peroxide (BPO) is widely utilized in acne treatment as an alternative to antibiotics against which Propionibacterium acnes becomes more resistant.

OBJECTIVE:

This overview examines BPO dose justification.

METHODS:

PubMed, EmbaseĀ® and Science Citation Index searches were conducted using the keywords "benzoyl peroxide" and "acne vulgaris".

RESULTS:

Limited experimental data are available. However, there appears no significant difference in the efficacy of concentrations from 2.5% to 10%.

DISCUSSION:

The extent of free fatty acids and the percutaneous penetration of BPO may not play a critical role in acne vulgaris.

PMID:
22103743
DOI:
10.3109/09546634.2011.641937
[Indexed for MEDLINE]
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