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Biochem Soc Trans. 2011 Dec;39(6):1725-8. doi: 10.1042/BST20110668.

The role of nesprins as multifunctional organizers in the nucleus and the cytoskeleton.

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1
Center for Biochemistry and Center for Molecular Medicine Cologne, Medical Faculty, and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Joseph-Stelzmann-Strasse 52, 50931 Cologne, Germany. noegel@uni-koeln.de

Abstract

Nesprins (nuclear envelope spectrin repeat proteins), also known as SYNE (synaptic nuclear envelope protein), MYNE (myocyte nuclear envelope protein), ENAPTIN and NUANCE, are proteins that are primarily components of the nuclear envelope. The nuclear envelope is a continuous membrane system composed of two lipid bilayers: an inner and an outer nuclear membrane. Nesprins are components of both nuclear membranes and reach into the nucleoplasm and the cytoplasm, where they undergo different interactions and have the potential to influence transcriptional processes and cytoskeletal activities.

PMID:
22103515
DOI:
10.1042/BST20110668
[Indexed for MEDLINE]
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