Format

Send to

Choose Destination
See comment in PubMed Commons below
Protein Sci. 2012 Feb;21(2):299-305. doi: 10.1002/pro.2002. Epub 2011 Dec 21.

Protein topology from predicted residue contacts.

Author information

1
Division of Mathematical Biology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom. wtaylor@nimr.mrc.ac.uk

Abstract

Residue contacts predicted from correlated positions in a multiple sequence alignment are often sparse and uncertain. To some extent, these limitations in the data can be overcome by grouping the contacts by secondary structure elements and enumerating the possible packing arrangements of these elements in a combinatorial manner. Strong interactions appear frequently but inconsistent interactions are down-weighted and missing interactions up-weighted. The resulting improved consistency in the predicted interactions has allowed the method to be successfully applied to proteins up to 200 residues in length which is larger than any structure previously predicted using sequence data alone.

PMID:
22102360
PMCID:
PMC3324774
DOI:
10.1002/pro.2002
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center