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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1160-4. doi: 10.1107/S1744309111029654. Epub 2011 Sep 6.

Structure of New Delhi metallo-β-lactamase 1 (NDM-1).

Author information

1
Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Oxford, Didcot, Oxon OX11 0FA, England.

Abstract

Antibiotic resistance in bacterial pathogens poses a serious threat to human health and the metallo-β-lactamase (MBL) enzymes are responsible for much of this resistance. The recently identified New Delhi MBL 1 (NDM-1) is a novel member of this family that is capable of hydrolysing a wide variety of clinically important antibiotics. Here, the crystal structure of NDM-1 from Klebsiella pneumoniae is reported and its structure and active site are discussed in the context of other recently deposited coordinates of NDM-1.

PMID:
22102018
PMCID:
PMC3212353
DOI:
10.1107/S1744309111029654
[Indexed for MEDLINE]
Free PMC Article

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