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Mol Med Rep. 2012 Feb;5(2):509-12. doi: 10.3892/mmr.2011.681. Epub 2011 Nov 16.

Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas.

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Department of Molecular Oncogenetics, Institute of Molecular Biology and Genetics, 03143 Kiev, Ukraine.


The leucine rich repeat containing 3B (LRRC3B) gene is a putative tumor suppressor located on human chromosome 3 in the 3p24 region. LRRC3B is frequently altered in colon and gastric cancers and also in leukaemias. In this study we investigated the promoter region methylation as a possible mechanism of LRRC3B gene inactivation in clear cell renal cell carcinomas. We found that the LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples. However, no correlation between DNA methylation and LRRC3B expression was found.

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