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Nanotechnology. 2011 Dec 9;22(49):494003. doi: 10.1088/0957-4484/22/49/494003. Epub 2011 Nov 21.

Micro- and nanotechnology in cardiovascular tissue engineering.

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Department of Chemical Engineering and Applied Chemistry, University of Toronto, 164 College Street, Rm 407, Toronto, ON M5S 3G9, Canada.


While in nature the formation of complex tissues is gradually shaped by the long journey of development, in tissue engineering constructing complex tissues relies heavily on our ability to directly manipulate and control the micro-cellular environment in vitro. Not surprisingly, advancements in both microfabrication and nanofabrication have powered the field of tissue engineering in many aspects. Focusing on cardiac tissue engineering, this paper highlights the applications of fabrication techniques in various aspects of tissue engineering research: (1) cell responses to micro- and nanopatterned topographical cues, (2) cell responses to patterned biochemical cues, (3) controlled 3D scaffolds, (4) patterned tissue vascularization and (5) electromechanical regulation of tissue assembly and function.

[Indexed for MEDLINE]

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