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Lancet. 2012 Feb 18;379(9816):662-71. doi: 10.1016/S0140-6736(11)60281-X. Epub 2011 Nov 17.

Chikungunya: a re-emerging virus.

Author information

1
Department of Medical Microbiology and Virology, National Health Laboratory Services Universitas and University of the Free State, Bloemfontein, South Africa. burtfj@ufs.ac.za

Abstract

In the past decade, chikungunya--a virus transmitted by Aedes spp mosquitoes--has re-emerged in Africa, southern and southeastern Asia, and the Indian Ocean Islands as the cause of large outbreaks of human disease. The disease is characterised by fever, headache, myalgia, rash, and both acute and persistent arthralgia. The disease can cause severe morbidity and, since 2005, fatality. The virus is endemic to tropical regions, but the spread of Aedes albopictus into Europe and the Americas coupled with high viraemia in infected travellers returning from endemic areas increases the risk that this virus could establish itself in new endemic regions. This Seminar focuses on the re-emergence of this disease, the clinical manifestations, pathogenesis of virus-induced arthralgia, diagnostic techniques, and various treatment modalities.

PMID:
22100854
DOI:
10.1016/S0140-6736(11)60281-X
[Indexed for MEDLINE]

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