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Autoimmun Rev. 2012 Jul;11(9):627-35. doi: 10.1016/j.autrev.2011.11.003. Epub 2011 Nov 12.

Origin and plasticity of MHC I-associated self peptides.

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Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montreal, Canada.


Endogenous peptides presented by MHC I molecules represent the essence of self for CD8 T lymphocytes. These MHC I peptides (MIPs) regulate all key events that occur during the lifetime of CD8 T cells. CD8 T cells are selected on self-MIPs, sustained by self-MIPs, and activated in the presence of self-MIPs. Recently, large-scale mass spectrometry studies have revealed that the self-MIP repertoire is more complex and plastic than previously anticipated. The composition of the self-MIP repertoire varies from one cell type to another and can be perturbed by cell-intrinsic and -extrinsic factors including dysregulation of cellular metabolism and infection. The complexity and plasticity of the self-MIP repertoire represent a major challenge for the maintenance of self tolerance and can have pervasive effects on the global functioning of the immune system.

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