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FEBS Lett. 2011 Dec 15;585(24):3890-7. doi: 10.1016/j.febslet.2011.11.013. Epub 2011 Nov 15.

Rvb2/reptin physically associates with telomerase in budding yeast.

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  • 1UMR CNRS 5239, Ecole Normale Sup√©rieure de Lyon, IFR128 BioSciences Gerland, Lyon, France.


Telomerase is a reverse transcriptase that maintains linear telomeres at a constant length. Here, we report that in the budding yeast Saccharomyces cerevisiae, Rvb2, a highly conserved member of the AAA+ family of ATPases, physically associates with telomerase/Est2 in vivo, both expressed from their endogenous promoter. Importantly, in genetic settings leading to a failure to recruit telomerase at telomeric ends, Rvb2 still associated with Est2. On the other hand, Rvb2 was present in immunoprecipitates of crosslinked telomeric chromatin even in the presumed absence of telomerase at the telomeres. Finally, we could also isolate RVB2 mutant alleles conferring slight, but stable, telomere shortening.

Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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