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Atherosclerosis. 2012 Jan;220(1):118-21. doi: 10.1016/j.atherosclerosis.2011.10.025. Epub 2011 Oct 29.

Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice.

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1
Department of Pathology/Section on Lipid Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, United States.

Abstract

INTRODUCTION:

The anti-atherogenic and hypotriglyceridemic properties of fish oil are attributed to its enrichment in eicosapentaenoic acid (EPA; 20:5, n-3) and docosahexaenoic acid (DHA; 22:6, n-3). Echium oil contains stearidonic acid (SDA; 18:4, n-3), which is metabolized to EPA in humans and mice, resulting in decreased plasma triglycerides.

OBJECTIVE:

We used apoB100 only, LDLrKO mice to investigate whether echium oil reduces atherosclerosis.

METHODS:

Mice were fed palm, echium, or fish oil-containing diets for 16 weeks and plasma lipids, lipoproteins, and atherosclerosis were measured.

RESULTS:

Compared to palm oil, echium oil feeding resulted in significantly less plasma triglyceride and cholesterol levels, and atherosclerosis, comparable to that of fish oil.

CONCLUSION:

This is the first report that echium oil is anti-atherogenic, suggesting that it may be a botanical alternative to fish oil for atheroprotection.

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