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Trends Biochem Sci. 2012 Jan;37(1):7-14. doi: 10.1016/j.tibs.2011.10.001. Epub 2011 Nov 16.

The enzymes of bacterial census and censorship.

Author information

1
Division of Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, TX 78712, USA. waltfast@mail.utexas.edu

Abstract

N-Acyl-L-homoserine lactones (AHLs) are a major class of quorum-sensing signals used by Gram-negative bacteria to regulate gene expression in a population-dependent manner, thereby enabling group behavior. Enzymes capable of generating and catabolizing AHL signals are of significant interest for the study of microbial ecology and quorum-sensing pathways, for understanding the systems that bacteria have evolved to interact with small-molecule signals, and for their possible use in therapeutic and industrial applications. The recent structural and functional studies reviewed here provide a detailed insight into the chemistry and enzymology of bacterial communication.

PMID:
22099187
PMCID:
PMC3259214
DOI:
10.1016/j.tibs.2011.10.001
[Indexed for MEDLINE]
Free PMC Article

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