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J Inorg Biochem. 2011 Nov;105(11):1513-7. doi: 10.1016/j.jinorgbio.2011.07.001. Epub 2011 Jul 23.

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

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Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6.


Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.

[Indexed for MEDLINE]

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