Format

Send to

Choose Destination
Emerg Infect Dis. 2011 Nov;17(11):2010-7. doi: 10.3201/eid1711.110159.

Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010.

Author information

1
The Methodist Hospital Research Institute, Houston, Texas 77030, USA.

Abstract

Group A Streptococcus (GAS) is a human-adapted pathogen that causes a variety of diseases, including pharyngitis and invasive infections. GAS strains are categorized by variation in the nucleotide sequence of the gene (emm) that encodes the M protein. To identify the emm types of GAS strains causing pharyngitis in Ontario, Canada, we sequenced the hypervariable region of the emm gene in 4,635 pharyngeal GAS isolates collected during 2002-2010. The most prevalent emm types varied little from year to year. In contrast, fine-scale geographic analysis identified inter-site variability in the most common emm types. Additionally, we observed fluctuations in yearly frequency of emm3 strains from pharyngitis patients that coincided with peaks of emm3 invasive infections. We also discovered a striking increase in frequency of emm89 strains among isolates from patients with pharyngitis and invasive disease. These findings about the epidemiology of GAS are potentially useful for vaccine research.

PMID:
22099088
PMCID:
PMC3310556
DOI:
10.3201/eid1711.110159
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center