Format

Send to

Choose Destination

RETRACTED ARTICLE

See: Retraction Notice

See comment in PubMed Commons below
Mult Scler Int. 2011;2011:246412. doi: 10.1155/2011/246412. Epub 2011 Jul 18.

Consensus Guidelines for CSF and Blood Biobanking for CNS Biomarker Studies.

Author information

1
Department of Clinical Chemistry, Neurological Laboratory and Biobank, VU University Medical Center, FdG, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands.

Abstract

There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in cerebrospinal fluid (CSF) are being used in clinical practice. Anti-aquaporin-4 antibodies in serum are currently useful for the diagnosis of neuromyelitis optica (NMO), but we could expect novel CSF biomarkers that help define prognosis and response to treatment for this disease. One of the most critical factors in biomarker research is the inadequate powering of studies performed by single centers. Collaboration between investigators is needed to establish large biobanks of well-defined samples. A key issue in collaboration is to establish standardized protocols for biobanking to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by pre-analytical factors. Here, consensus guidelines for CSF collection and biobanking are presented, based on the guidelines that have been published by the BioMS-eu network for CSF biomarker research. We focussed on CSF collection procedures, pre-analytical factors and high quality clinical and paraclinical information. Importantly, the biobanking protocols are applicable for CSF biobanks for research targeting any neurological disease.

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center